The necessarily mean continuous point out quantity of distribution (Vss) for sildenafil is one zero five L, indicating distribution in to the tissues. Sildenafil and its important circulating N-desmethyl metabolite are equally approximately 96% sure to plasma proteins. Protein binding is unbiased of total drug concentrations.
irregular vision, which include alterations in shade eyesight (like getting a blue coloration tinge) and blurred vision
Examination of the security database from managed clinical trials confirmed no evident difference in adverse reactions in patients taking VIAGRA with and without having anti-hypertensive medication.
This Investigation was done retrospectively, and was not driven to detect any pre-specified difference in adverse reactions.
Det er viktig at du ikke kombinerer denne potenspillen med andre legemidler uten at du har opplyst legen om at du bruker disse medisinene.
Sildenafil er forsåvidt en direkte kopi av Viagra som inneholder den samme mengden virkestoff og fungerer på samme måte som originalen.
an erection that won't go away (priapism). For those who have an erection that lasts more than four hours, get health-related assistance straight away. If It's not necessarily taken care of immediately, priapism can forever injury your penis.
Sexual exercise can set an extra strain in your coronary heart, particularly if your coronary heart is previously weak from a heart attack or heart disease. Request your health practitioner if your heart is healthier ample to manage the additional pressure of having intercourse.
Significant coronary heart signs and symptoms such as quickly, irregular, or pounding heartbeats; fluttering with your upper body; shortness of breath; and unexpected dizziness, lightheartedness, or passing out;
are allergic to sildenafil, as contained in VIAGRA and REVATIO, or any of the components in VIAGRA. See the conclusion of the leaflet more info for an entire list of substances in VIAGRA.
Effekten av Viagra Reseptfri er midlertidig og ikke en kur mot erektil dysfunksjon, og person får ikke effekt dersom seksuell stimuli uteblir.
So, the metabolite is responsible for about twenty% of sildenafil's action. Sildenafil is excreted as metabolites predominantly in the feces (about 80% of administered oral dose) and to a lesser extent from the urine (close to thirteen% in the administered oral dose). If taken which has a large-Excess fat meal, absorption is lessened; enough time taken to achieve the maximum plasma concentration will increase by all-around just one hour, and the utmost focus by itself is reduced by virtually 1-3rd.[52]
Signify sildenafil plasma concentrations measured following the administration of just one oral dose of 100 mg to healthier male volunteers is depicted under:
Doctors must explore with individuals the contraindication of VIAGRA with frequent and/or intermittent utilization of nitric oxide donors, like organic and natural nitrates or organic and natural nitrites in almost any sort [see CONTRAINDICATIONS].